Characterization of HIV-1-specific antibodies and HIV-1-crossreactive antibodies to platelets in HIV-1-infected haemophiliac patients
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چکیده
منابع مشابه
Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.
Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Autologous nAb titers of study exit plasma against study entry viruses were significantly higher tha...
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Background: Due to some limitations of serological methods in diagnosis of patients infected with HIV-1 (human immunodeficiency virus) and HCV (hepatitis C virus), it is profoundly important to use molecular methods for the detecting of these infectious agents. However, the most significant problems are the exorbitant cost of these methods and the need of a thermocycler which is an expensive...
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12 Los Alamos National Laboratory and New Mexico Consortium, Los Alamos, New Mexico, United 13 States of America 14 Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America 15 Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America 16 Duke University Medical Center, Durham, North Carolina, United States of America 17 US M...
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Both CD4+ T cells and macrophages are major reservoirs of HIV-1. Previous study showed that HIV-1-specific cytolytic T lymphocytes (CTLs) hardly recognize HIV-1-infected CD4+ T cells because of Nef-mediated HLA class I down-regulation, suggesting that HIV-1 escapes from HIV-1-specific CTLs and continues to replicate in HIV-1-infected donors. On the other hand, the CTL recognition of HIV-1-infec...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1998
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.1998.01116.x